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Research | Core Facilities | Patient Studies | Tech Transfer | Seminars | Intranet | Jobs | Search | Contact Us | Ways To Give HOME |
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Clinical Pharmacology Research Program Meet the scientists in this program Recent Scientific Publications Download - Review of Systemic Lupus
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The overall goal of the Clinical Pharmacology Research Program, headed by Joan T. Merrill, M.D., is to enhance translational research at OMRF, linking basic research discoveries to clinical trials in patients. The program currently focuses on cardiovascular and immune-modifying therapies. Recent scientific work has helped to illuminate the specific kinds of blood vessel damage caused by lupus, atherosclerosis, hypertension and diabetes on a molecular level. This has led to new ideas for immune-regulating and blood-vessel-regulating therapies for these diseases. But while there are now several new classes of medicine in the pipeline to treat these life-threatening diseases, we have much to learn about the best dosing and timing to optimize the effectiveness of these new drugs and how to minimize their potential side effects. Traditionally, gaps have existed between the basic scientific work that gives rise to new medicines and the process by which physicians test these treatments in humans. By connecting basic science investigations directly to clinical trials, we are creating a two-way scientific synergy. Input from the laboratory will help clinicians better understand how the medicines work and how to use them with optimal safety and effectiveness. conversely, materials donated by patients in clinical trials may shed important light on the fundamental problems that cause disease in the first place. With the help of applied laboratory science, this information may lead to even better medicines in the future.
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