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Immunobiology and Cancer Research Program

Meet the scientists in this program

The Immunobiology and Cancer Research Program, led by Paul W. Kincade, Ph.D., is principally concerned with understanding the normal development and function of cells in the immune system. We hope this research will, in turn, help shed light on disease, as abnormalities in these processes result in leukemia, lymphomas and immunodeficiency diseases. Although astonishing progress has been made, we have much to learn if we are truly to conquer these conditions.

Work in all five laboratories in this program progressed in important ways during the last year. Xiao-Hong Sun, Ph.D., obtained new insights into how highly controlled, cell-type specific degradation mechanisms can help regulate a family of transcription factors. Work in the laboratory of Carol Webb, Ph.D., revealed important interactions between Bruton's tyrosine kinase and the activity of the Bright transcription factor.

Using an exciting new strain of knockout mice, Linda Thompson, Ph.D., and colleagues found an important role for the CD73 ectoenzyme in hypoxia. Mark Coggeshall, Ph.D., and his lab found intracellular signaling pathways that keep immune system responses within normal ranges. Finally, Kincade and his colleagues have now identified the earliest lymphocyte progenitors within murine bone marrow as well as the very beginning of the immune system during fetal life.