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Arthritis and Immunology Research Program

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OMRF receives $26 million for two federal research grants

Jonathan D. Wren, Ph.D. Assistant Member, Arthritis and Immunology Research Program

Past Projects
My interests have been somewhat diverse. I've worked on a variety of projects, beginning with image enhancement for sequence data and moving on to methods of predicting polymorphic sequence repeats within mammalian genomes. Our predictive methods turned out to be surprisingly accurate, so we refined and applied our rule set more specifically to polymorphisms in transcribed regions and studied the acquisition of somatically acquired polymorphisms in cancer cells. A colleague & co-author of mine later discovered that these repetitive regions in genes enable rapid evolutionary "tweaking" of quantitative parameters such as the length of a dog's snout, providing an important new chapter in the book on evolution. I've developed a freeware package for basic sequence analysis and manipulation, conducted a study on microarray cross-hybridization, aided in the design of microarray analysis tools and designed a set of acronym recognition heuristics to aid in literature-based text analysis which led to the creation of a near-comprehensive biomedical acronym database (Google search, top hit and featured in the Netwatch section of Science).

Mailing Address
Arthritis and Immunology Research Program, MS 58
Oklahoma Medical Research Foundation
825 N.E. 13th Street
Oklahoma City, Oklahoma 73104

Contact Information
Phone: (405) 271-6989
Fax: (405) 271-4110