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Arthritis and Immunology Research Program

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OMRF researcher finds genetic links for rare and deadly disease

Amr H. Sawalha, M.D. Assistant Member, Arthritis and Immunology Research Program Assistant Professor of Medicine, Department of Medicine, University of Oklahoma   Health Science Center Staff Physician, U.S. Department of Veterans Affairs Medical Center, Oklahoma City

Recent Publications
Fei Y, Webb R, Cobb BL, Direskeneli H, Saruhan-Direskeneli G, Sawalha AH. Identification of novel genetic susceptibility loci for Behcet's disease using a genome-wide association study. Arthritis Res Ther 11:R66, 2009. [Abstract]

Sawalha AH, Harley JB, Scofield RH. Autoimmunity and Klinefelter's syndrome: When men have two X chromosomes. J Autoimmun 33:31-34, 2009. [Abstract]

Li Y, Sawalha AH, Lu Q. Aberrant DNA methylation in skin diseases. J Dermatol Sci 54:143-149, 2009. [Abstract]

Selected Publications
Sawalha AH, Jeffries M. Defective DNA methylation and CD70 overexpression in CD4+ T cells in MRL/lpr lupus-prone mice. Eur J Immunol 37:1407-1413, 2007 [Abstract]

Sawalha AH, Jeffries M, Webb R, Lu Q, Gorelik G, Ray D, Osban J, Knowlton N, Johnson K, Richardson B. Defective T-cell ERK signaling induces interferon-regulated gene expression and overexpression of methylation-sensitive genes similar to lupus patients. Genes Immun 9:368-378, 2008. [Abstract]

Sawalha AH, Kaufman KM, Kelly JA, Adler AJ, Aberle T, Kilpatrick J, Wakeland EK, Li QZ, Wandstrat AE, Karp DS, James JA, Merrill JT, Lipsky P, Harley JB. Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus. Ann Rheum Dis 67:458-461, 2008. [Abstract]

Sawalha AH, Webb R, Han S, Kelly JA, Kaufman KM, Kimberly RP, Alarcon-Riquelme ME, James JA, Vyse TJ, Gilkeson GS, Choi CB, Scofield RH, Bae SC, Nath SK, Harley JB. Common variants within MECP2 confer risk of Systemic Lupus Erythematosus. PLoS ONE 3:e1727, 2008. [Abstract]

Gorelik G, Fang JY, Wu A, Sawalha AH, Richardson B. Impaired T cell protein kinase C{delta} activation decreases ERK pathway signaling in idiopathic and hydralazine-induced lupus. J Immunol 179:5553-5563, 2007. [Abstract]

Sawalha AH. Epigenetics and T-cell immunity. Autoimmunity 41:245-252, 2008. [Abstract]