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More about Dr. Gray-McGuire 101 Dr. Gray-McGuire's CV in brief Arthritis and Immunology Research Program Dr. Gray-McGuire In The News OMRF researchers receive $14.7 million in federal stimulus grant funding OMRF receives $26 million for two federal research grants
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Research Interests Colorectal cancer is the second leading cause of cancer mortality in adult Americans with each American carrying a 6% lifetime risk of developing the disease. While early stage cancers can be highly curable, late stage colon cancers remain incurable. Both somatic and germline mutations have been associated with the development of colon cancer and its precursor adenomatous colon polyps (ACPs). However, familial colon cancers with known cause: Familial Adenomatous Polyposis (FAP) and Hereditary Nonpolyposis Colorectal Cancer (HNPCC) account for <1% and ~5% of all colon cancer cases annually, respectively. Our studies, in collaboration with our colleagues at Case Western Reserve University, are aimed at identifying additional alleles predisposing to colon neoplasia vital to describing individuals at high risk for developing colon cancer, and for whom colon cancer screening and early detection can have potentially life-saving benefits. SLE is a systemic autoimmune disease most frequently and severely affecting women and has diverse clinical manifestations involving the joints, kidneys, brain, and several other organ systems. OMRF and our studies have played a major role in a longstanding effort devoted to identifying genes involved in SLE. The focus of my most recent work in this area is the identification of genes involved in the targets of the earliest autoimmune response. Identification of these genes would give us insight into the biological mechanisms underlying SLE and, potentially, other autoimmune disorders and therefore the ability to intervene in disease progression before or at the earliest stages of clinical presentation. Sarcoidosis, a systemic granulomatous disease, has been associated with various environmental exposures and infectious agents, as well as family history. It is characterized by the presence of granulomas in the liver, lymph glands, bone marrow, brain, and most frequently, the lungs. Sarcoidosis is more prevalent in women and, in the United States, African Americans are both more commonly and more severely affected than Caucasians. Our studies, together with our collaborators at Henry Ford Health Systems, have identified a major genetic component on chromosome 5 unique to African Americans. Current studies focus on using ancestry-specific information to help elucidate the exact location of these genes. Joined OMRF Scientific Staff in 2008. Mailing Address
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