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Dr. Gaffney:

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Dr. Gaffney's CV in brief

Publications

Arthritis and Immunology Research Program

Dr. Gaffney In The News

OMRF researchers receive $14.7 million in federal stimulus grant funding

OMRF welcomes new board members, honors scientists

Reckless Driving: OMRF discovers gene variant that "cuts the brakes' on immune system in lupus patients

Patrick M. Gaffney, M.D. Associate Member, Arthritis and Immunology Research Program

Research Interests
Improving our understanding of the genetic basis of systemic lupus erythematosus (SLE) is a major focus of the work in our laboratory. SLE is a prototypic autoimmune disease characterized by the production of antibodies that react with a wide variety of tissues resulting in systemic inflammation and organ failure.

From over a decade of work on the genetics of SLE, it is now clear that the risk of developing SLE is strongly influenced by genetic polymorphisms inherited within families. We use rapid high-capacity genotyping technology to systematically evaluate genetic polymorphisms associated with human SLE. With the completion of our genome-wide association study many new genetic targets will be identified and will require further replication. We are engaged in all phases of genetic evaluation from discovery to validation to functional characterization in model systems. The overall objective of these studies is to develop a comprehensive view of the genetic landscape of SLE and then use that information to develop new and improved treatments, predictive tools and monitoring programs for patients with SLE.

Joined OMRF Scientific Staff in 2007.

Mailing Address
Arthritis and Immunology Research Program, MS 57
Oklahoma Medical Research Foundation
825 N.E. 13th Street
Oklahoma City, Oklahoma 73104

Contact Information
Phone: (405) 271-2572
Fax: (405) 271-3045
E-mail: Patrick-Gaffney@omrf.org