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Publications

Protein Studies Research Program

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American Association for the Advancement of Science selects OMRF scientist as Fellow

Jordan J. N. Tang, Ph.D. Member and Program Chair, Protein Studies Research Program J.G. Puterbaugh Chair in Medical Research Adjunct Professor, Department of Biochemistry and Molecular Biology, University   of Oklahoma Health Sciences Center

Recent Publications
Minogue AM, Stubbs AK, Frigerio CS, Boland B, Fadeeva JV, Tang J, Selkoe DJ, Walsh DM. gamma-secretase processing of APLP1 leads to the production of a p3-like peptide that does not aggregate and is not toxic to neurons. Brain Res 1262:89-99, 2009. [Abstract]

Ghosh AK, Gemma S, Tang J. Beta-secretase as a therapeutic target for Alzheimer's disease. Neurotherapeutics 5:399-408, 2008. [Abstract]

Ghosh AK, Kumaragurubaran N, Hong L, Koelsh G, Tang J. Memapsin 2 (beta-secretase) inhibitors: drug development. Curr Alzheimer Res 5:121-131, 2008. [Abstract]

Selected Publications
He X, Zhu G, Koelsch G, Rodgers KK, Zhang XC, Tang, J. Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins. Biochemistry 42:12174-80. 2003. [Abstract]

Zhai P, He X, Liu J, Wakeham N, Zhu G, Li G, Tang J, Zhang XC. The interaction of human GGA1 GAT domain with Rabaptin-5 is mediated by residues on its three-helix bundle. Biochemistry 42:13901-8, 2003. [Abstract]

Koelsch G, Turner RT, Hong L, Ghosh AK, Tang J. Memapsin 2, a drug target for Alzheimer's disease. In: Saklatvala J, Nagase H, Salvesen G, editors, Proteases and the Regulation of Biological Processes, pp. 213-220, 2003.

Ghosh AK, Hong L, Tang J. Beta-secretase as a therapeutic target for inhibitor drugs. Curr Med Chem 9:1135-1144, 2002. [Abstract]

He X, Chang WP, Koelsch G, Tang J. Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2. FEBS Lett 524:183-187, 2002. [Abstract]

Hong L, Turner RT 3rd, Koelsch G, Shin D, Ghosh AK, Tang J. Crystal structure of memapsin 2 (beta-secretase) in complex with an inhibitor OM00-3. Biochemistry 41:10963-10967, 2002. [Abstract]