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Dr. Rankin:

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Cell Cycle and Cancer Biology Research Program

Dr. Rankin In The News

OMRF cell biologist honored as Oklahoma's first Pew Scholar

Susannah Rankin, Ph.D. Assistant Member, Cell Cycle and Cancer Biology Research Program

Research Interests
I am interested in sister chromatid cohesion and how cell cycle progression coordinates this process. Though first observed and appreciated many decades ago, the mechanism of sister chromatid cohesion remains poorly understood. The study of chromatid cohesion has been hampered by several factors: features buried in the complexity of chromatin structure, inadequate assays, redundant mechanisms, and a lack of sequence conservation among species.

We recently discovered a cell cycle-regulated protein, sororin, that is required for sister chromatid cohesion in vertebrates. In my laboratory we are investigating the mechanism of action of sororin and how it functions in the context of other known cohesion factors and activities. We are also pursuing a broad-based inquiry into sister chromatid cohesion and the effects of its failure on genome stability in higher eukaryotes.

Joined OMRF Scientific Staff in 2006.

Mailing Address
Cell Cycle and Cancer Biology Research Program, MS 48
Oklahoma Medical Research Foundation
825 N.E. 13th Street
Oklahoma City, Oklahoma 73104

Contact Information
Phone: (405) 271-8190
Fax: (405) 271-7312
E-mail: Susannah-Rankin@omrf.org