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Scientific Publications

OMRF Publications For 2005

Arthritis Research Program 

* Aston,C.E., D.A.Ralph, D.P.Lalo, S.Manjeshwar, B.A.Gramling, D.C.Defreese, A.D.West, D.E.Branam, L.F.Thompson, M.A.Craft, D.S.Mitchell, C.D.Shimasaki, J.J.Mulvihill, and E.R.Jupe. 2005. Oligogenic combinations associated with breast cancer risk in women under 53 years of age. Hum.Genet. 116:208-221. [Abstract]

Bruner,B.F., D.M.Wynn, M.Reichlin, J.B.Harley, and J.A.James. 2005. Humoral antigenic targets of the ribosomal p0 lupus autoantigen are not limited to the carboxyl region. Ann.N.Y.Acad.Sci. 1051:390-403. [Abstract]

Dozmorov,I.M., M.Centola, N.Knowlton, and Y.Tang. 2005. Mobile classification in microarray experiments. Scand.J Immunol. 62 Suppl 1:84-91. [Abstract]

Hannan,J.P., K.A.Young, J.M.Guthridge, R.Asokan, G.Szakonyi, X.S.Chen, and V.M.Holers. 2005. Mutational analysis of the complement receptor type 2 (CR2/CD21)-C3d interaction reveals a putative charged SCR1 binding site for C3d. J Mol Biol 346:845-858. [Abstract]

Lee, Y.H., T.Witte, T.Momot, R.E.Schmidt, K.M.Kaufman, J.B.Harley, and A.L.Sestak. 2005. The mannose-binding lectin gene polymorphisms and systemic lupus erythematosus: Two case-control studies and a meta-analysis. Arthritis Rheum 52:3966-3974. [Abstract]

Huang,H., M.B.Frank, I.Dozmorov, W.Cao, C.Cadwell, N.Knowlton, M.Centola, and R.E.Anderson. 2005. Identification of mouse retinal genes differentially regulated by dim and bright cyclic light rearing. Exp Eye Res 80:727-739. [Abstract]

Jarvis,J.N. and M.Centola. 2005. Gene-expression profiling: time for clinical application? Lancet 365:199-200.  [Abstract]

Kim-Howard,X.R., L.Staudt, and J.A.James. 2005. Update in rheumatoid arthritis therapy. J Okla.State Med Assoc. 98:53-62. [Abstract]

Kochi,Y., R.Yamada, A.Suzuki, J.B.Harley, S.Shirasawa, T.Sawada, S.C.Bae, S.Tokuhiro, X.Chang, A.Sekine, A.Takahashi, T.Tsunoda, Y.Ohnishi, K.M.Kaufman, C.P.Kang, C.Kang, S.Otsubo, W.Yumura, A.Mimori, T.Koike, Y.Nakamura, T.Sasazuki, and K.Yamamoto. 2005. A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities. Nat.Genet. 37:478-485. [Abstract]

Kurella,S., J.C.Yaciuk, I.Dozmorov, M.B.Frank, M.Centola, and A.D.Farris. 2005. Transcriptional modulation of TCR, Notch and Wnt signaling pathways in SEB-anergized CD4+ T cells. Genes Immun. 6:596-608. [Abstract]

Kurien,B.T., S.Asfa, C.Li, Y.Dorri, R.Jonsson, and R.H.Scofield. 2005. Induction of Oral Tolerance in Experimental Sjogren's Syndrome Autoimmunity. Scand.J Immunol. 61:418-425. [Abstract]

Kurien,B.T., T.Gross, and R.H.Scofield. 2005. Barbering in mice: a model for trichotillomania. BMJ 331:1503-1505. [Abstract]

Lee,Y.H., J.B.Harley, and S.K.Nath. 2005. CTLA-4 polymorphisms and systemic lupus erythematosus (SLE): a meta-analysis. Hum.Genet. 116:361-7. [Abstract]

McClain,M.T., L.D.Heinlen, G.J.Dennis, J.Roebuck, J.B.Harley, and J.A.James. 2005. Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry. Nat.Med. 11:85-89. [Abstract]

Miner,J., M.M.Gillan, P.Alex, and M.Centola. 2005. Steroid-refractory ulcerative colitis treated with corticosteroids, metronidazole and vancomycin: a case report. BMC Gastroenterol. 5:3.  [Abstract]

Namjou,B., J.A.Kelly, J.Kilpatrick, K.M.Kaufman, S.K.Nath, R.H.Scofield, and J.B.Harley. 2005. Linkage at 5q14.3-15 in multiplex systemic lupus erythematosus pedigrees stratified by autoimmune thyroid disease. Arthritis Rheum 52:3646-3650. [Abstract]

Nath,S.K., J.B.Harley, and Y.H.Lee. 2005. Polymorphisms of complement receptor 1 and interleukin-10 genes and systemic lupus erythematosus: a meta-analysis. Hum.Genet. 118:225-234. [Abstract]

Naylor,M. 2005. Imiquimod and superficial skin cancers. J Drugs Dermatol 4:598-606. [Abstract]

Nolsoe,R.L., J.A.Kelly, F.Pociot, K.L.Moser, O.P.Kristiansen, T.Mandrup-Poulsen, and J.B.Harley. 2005. Functional promoter haplotypes of the human FAS gene are associated with the phenotype of SLE characterized by thrombocytopenia. Genes Immun. 6:699-706. [Abstract]

Reichlin,M. 2005. Serological correlations with nephritis in systemic lupus erythematosus. Clin.Immunol. 117:12-14. [Abstract]

*  Rodgers,W., D.Farris, and S.Mishra. 2005. Merging complexes: properties of membrane raft assembly during lymphocyte signaling. Trends Immunol. 26:97-103.  [Abstract]

Sarkar,K., C.R.Weinberg, C.V.Oddis, T.A.Medsger Jr, P.H.Plotz, J.D.Reveille, F.C.Arnett, I.N.Targoff, E.Genth, L.A.Love, and F.W.Miller. 2005. Seasonal influence on the onset of idiopathic inflammatory myopathies in serologically defined groups. Arthritis Rheum 52:2433-2438.  [Abstract]

Scofield,R.H., S.Asfa, D.Obeso, R.Jonsson, and B.T.Kurien. 2005. Immunization with Short Peptides from the 60-kDa Ro Antigen Recapitulates the Serological and Pathological Findings as well as the Salivary Gland Dysfunction of Sjogren's Syndrome. J Immunol 175:8409-8414. [Abstract]

* Scofield, R.H., B.T.Kurien, S.Ganick, M.T.McClain, Q.Pye, J.A.James, R.I.Schneider, R.H.Broyles, M.Bachmann, and K.Hensley. 2005. Modification of lupus-associated 60-kDa Ro protein with the lipid oxidation product 4-hydroxy-2-nonenal increases antigenicity and facilitates epitope spreading. Free Radic.Biol Med 38:719-728. [Abstract]

Sestak,A.L., S.K.Nath, and J.B.Harley. 2005. Genetics of systemic lupus erythematosus: how far have we come? Rheum Dis.Clin.North Am. 31:223-244. [Abstract]

Szodoray,P., P.Alex, M.V.Jonsson, N.Knowlton, I.Dozmorov, B.Nakken, N.Delaleu, R.Jonsson, and M.Centola. 2005. Distinct profiles of Sjogren's syndrome patients with ectopic salivary gland germinal centers revealed by serum cytokines and BAFF. Clin.Immunol. 117:168-176. [Abstract]

Troyanov,Y., I.N.Targoff, J.L.Tremblay, J.R.Goulet, Y.Raymond, and J.L.Senecal. 2005. Novel classification of idiopathic inflammatory myopathies based on overlap syndrome features and autoantibodies: analysis of 100 French Canadian patients. Medicine (Baltimore) 84:231-249.  [Abstract]

Wright,H., P.Alex, T.Nguyen, T.Bader, A.Gurakar, A.Sebastian, L.Gonzales, G.Wallis, M.Naylor, I.Dozmorov, M.Centola, and B.Nour. 2005. Multiplex cytokine profiling of initial therapeutic response in patients with chronic hepatitis C virus infection. Dig.Dis.Sci. 50:1793-1803. [Abstract]

Xing,C., C.Gray-McGuire, J.A.Kelly, P.Garriott, H.Bukulmez, J.B.Harley, and J.M.Olson. 2005. Genetic linkage of systemic lupus erythematosus to 13q32 in African American families with affected male members. Hum.Genet. 118:309-321. [Abstract]

Yu,X., Y.Tang, F.Li, M.B.Frank, H.Huang, I.Dozmorov, Y.Zhu, M.Centola, and W.Cao. 2005. Protection against hydrogen peroxide-induced cell death in cultured human retinal pigment epithelial cells by 17beta-estradiol: A differential gene expression profile. Mech.Ageing Dev.  126:1135-1145.  [Abstract]

Zhang,W. and M.Reichlin. 2005. A peptide DNA surrogate that binds and inhibits anti-dsDNA antibodies. Clin.Immunol. 117: 214-20. [Abstract]

Zhang,W. and M.Reichlin. 2005. Production and characterization of a human monoclonal anti-idiotype to anti-ribosomal P antibodies. Clin.Immunol. 114:130-136.  [Abstract]

Cardiovascular Biology Research Program

Belczewski,A.R., J.Ho, F.B.Taylor, Jr., M.B.Boffa, Z.Jia, and M.L.Koschinsky. 2005. Baboon lipoprotein(a) binds very weakly to lysine-agarose and fibrin despite the presence of a strong lysine-binding site in apolipoprotein(a) kringle IV type 10. Biochemistry 44:555-564.  [Abstract]

Bochner,B.S., R.A.Alvarez, P.Mehta, N.V.Bovin, O.Blixt, J.R.White, and R.L.Schnaar. 2005. Glycan array screening reveals a candidate ligand for Siglec-8. J Biol Chem 280:4307-4312. [Abstract]

Clayton F, Pysher TJ, Lou R, Kohan DE, Denkers ND, Tesh VL, Taylor FB, Jr., Siegler RL. Lipopolysaccharide upregulates renal shiga toxin receptors in a primate model of hemolytic uremic syndrome. Am J Nephrol 25:536-540, 2005. [Abstract]

Esmon,C. 2005. Do-all receptor takes on coagulation, inflammation. Nat.Med 11:475-477.

Esmon,C.T. 2005. Coagulation inhibitors in inflammation. Biochem Soc.Trans. 33:401-405. [Abstract]

Esmon,C.T. 2005. Inflammation and coagulation. Hematology 10 Suppl 1:40. [Abstract]

Esmon,C.T. 2005. Is APC activation of endothelial cell PAR1 important in severe sepsis?: No. J Thromb Haemost 3:1910-1911. [Abstract]

Heymans,S., F.Lupu, S.Terclavers, B.Vanwetswinkel, J.M.Herbert, A.Baker, D.Collen, P.Carmeliet, and L.Moons. 2005. Loss or inhibition of uPA or MMP-9 attenuates LV remodeling and dysfunction after acute pressure overload in mice. Am.J Pathol. 166:15-25.  [Abstract]

Hinsdale,M.E. and N.Maeda. 2005. Complex control of mouse apolipoprotein B gene expression revealed by targeted duplication. Biochim.Biophys Acta 1734:178-189. [Abstract]

Karmakar,S., R.D.Cummings, and R.P.McEver. 2005. Contributions of Ca2+ to galectin-1-induced exposure of phosphatidylserine on activated neutrophils. J Biol Chem 280:28623-28631. [Abstract]

Kinasewitz,G.T., J.G.Zein, G.L.Lee, S.A.Nazir, and F.B.Taylor, Jr. 2005. Prognostic value of a simple evolving disseminated intravascular coagulation score in patients with severe sepsis. Crit Care Med 33:2214-2221. [Abstract]

Li,W., X.Zheng, J.M.Gu, G.L.Ferrell, M.Brady, N.L.Esmon, and C.T.Esmon. 2005. Extraembryonic expression of EPCR is essential for embryonic viability. Blood 106:2716-2722.  [Abstract]

Li,W., X.Zheng, J.Gu, J.Hunter, G.L.Ferrell, F.Lupu, N.L.Esmon, and C.T.Esmon. 2005. Overexpressing endothelial cell protein C receptor alters the hemostatic balance and protects mice from endotoxin. J Thromb Haemost 3:1351-1359. [Abstract]

Ludeman,M.J., H.Kataoka, Y.Srinivasan, N.Esmon, C.T.Esmon, and S.R.Coughlin. 2005. PAR1 cleavage and signaling in response to activated protein C and thrombin. J Biol Chem. 280:13122-8. [Abstract]

Lupu,C., X.Hu, and F.Lupu. 2005. Caveolin-1 enhances tissue factor pathway inhibitor exposure and function on the cell surface. J Biol Chem. 280:22308-17. [Abstract]

Lupu,C., A.D.Westmuckett, G.Peer, L.Ivanciu, H.Zhu, F.B.Taylor, Jr., and F.Lupu. 2005. Tissue Factor-Dependent Coagulation Is Preferentially Up-Regulated within Arterial Branching Areas in a Baboon Model of Escherichia coli Sepsis. Am.J Pathol. 167:1161-1172. [Abstract]

Marshall,B.T., K.K.Sarangapani, J.Lou, R.P.McEver, and C.Zhu. 2005. Force history dependence of receptor-ligand dissociation. Biophys J 88:1458-1466.  [Abstract]

Mazo,I.B., M.Honczarenko, H.Leung, L.L.Cavanagh, R.Bonasio, W.Weninger, K.Engelke, L.Xia, R.P.McEver, P.A.Koni, L.E.Silberstein, and U.H.von Andrian. 2005. Bone marrow is a major reservoir and site of recruitment for central memory CD8(+) T cells. Immunity 22:259-270. [Abstract]

McEver,R.P. 2005. A sulfated address for lymphocyte homing. Nat.Immunol 6:1067-1069. [Abstract]

Ny,A., M.Koch, M.Schneider, E.Neven, R.T.Tong, S.Maity, C.Fischer, S.Plaisance, D.Lambrechts, C.Heligon, S.Terclavers, M.Ciesiolka, R.Kalin, W.Y.Man, I.Senn, S.Wyns, F.Lupu, A.Brandli, K.Vleminckx, D.Collen, M.Dewerchin, E.M.Conway, L.Moons, R.K.Jain, and P.Carmeliet. 2005. A genetic Xenopus laevis tadpole model to study lymphangiogenesis. Nat.Med 11:998-1004. [Abstract]

Safa,O., C.T.Esmon, and N.L.Esmon. 2005. Inhibition of APC anticoagulant activity on oxidized phospholipid by anti-{beta}2-glycoprotein I monoclonal antibodies. Blood 106:1629-1635. [Abstract]

Sesin,C.A., X.Yin, C.T.Esmon, J.P.Buyon, and R.M.Clancy. 2005. Shedding of endothelial protein C receptor contributes to vasculopathy and renal injury in lupus: in vivo and in vitro evidence. Kidney Int. 68:110-120. [Abstract]

Siegler,R.L., T.J.Pysher, V.L.Tesh, M.Noris, P.Cassis, and F.B.Taylor, Jr. 2005. Reduced nitric oxide bioavailability in a baboon model of Shiga toxin mediated hemolytic uremic syndrome (HUS). Ren Fail. 27:635-641. [Abstract]

* Yao,L., T.Yokota, L.Xia, P.W.Kincade, and R.P.McEver. 2005. Bone marrow dysfunction in mice lacking the cytokine receptor gp130 in endothelial cells. Blood  106:4093-101. [Abstract]

Zhu,C., J.Lou, and R.P.McEver. 2005. Catch bonds: Physical models, structural bases, biological function and rheological relevance. Biorheology 42:443-462. [Abstract]

Zhu C, McEver RP. Catch bonds: physical models and biological functions. Mol Cell Biomech 2:91-104, 2005. [Abstract]

Clinical Pharmacology Research Program

Binder,S.R., M.C.Genovese, J.T.Merrill, R.I.Morris, and A.L.Metzger. 2005. Computer-assisted pattern recognition of autoantibody results. Clin.Diagn.Lab Immunol 12:1353-1357. [Abstract]

Buyon,J.P., M.A.Petri, M.Y.Kim, K.C.Kalunian, J.Grossman, B.H.Hahn, J.T.Merrill, L.Sammaritano, M.Lockshin, G.S.Alarcon, S.Manzi, H.M.Belmont, A.D.Askanase, L.Sigler, M.A.Dooley, J.Von Feldt, W.J.McCune, A.Friedman, J.Wachs, M.Cronin, M.Hearth-Holmes, M.Tan, and F.Licciardi. 2005. The effect of combined estrogen and progesterone hormone replacement therapy on disease activity in systemic lupus erythematosus: a randomized trial. Ann.Intern.Med 142:953-962. [Abstract]

Ginzler,E.M., M.A.Dooley, C.Aranow, M.Y.Kim, J.Buyon, J.T.Merrill, M.Petri, G.S.Gilkeson, D.J.Wallace, M.H.Weisman, and G.B.Appel. 2005. Mycophenolate mofetil or intravenous cyclophosphamide for lupus nephritis. N.Engl.J Med 353:2219-2228. [Abstract]

Merrill,J.T. 2005. Emergence of targeted immune therapies for systemic lupus. Expert.Opin.Emerg.Drugs 10:53-65. [Abstract]

Merrill,J.T. 2005. BLyS antagonists and peptide tolerance induction. Lupus 14:204-209. [Abstract]

Merrill,J.T. and J.P.Buyon. 2005. The role of biomarkers in the assessment of lupus. Best Pract.Res Clin.Rheumatol. 19:709-726. [Abstract]

Olech,E. and J.T.Merrill. 2005. DHEA supplementation: the claims in perspective. Cleve.Clin.J Med 72:965-1. [Abstract]

Petri,M., M.Y.Kim, K.C.Kalunian, J.Grossman, B.H.Hahn, L.R.Sammaritano, M.Lockshin, J.T.Merrill, H.M.Belmont, A.D.Askanase, W.J.McCune, M.Hearth-Holmes, M.A.Dooley, J.Von Feldt, A.Friedman, M.Tan, J.Davis, M.Cronin, B.Diamond, M.Mackay, L.Sigler, M.Fillius, A.Rupel, F.Licciardi, and J.P.Buyon. 2005. Combined oral contraceptives in women with systemic lupus erythematosus. N.Engl.J Med 353:2550-2558. [Abstract]

Crystallography Research Program

Zhu G, P.Zhai, N.Wakeham, X.He, and X.C.Zhang. Analysis of the interaction between GGA1 GAT domain and Rabaptin-5. Methods Enzymol 403:583-592, 2005. [Abstract]

Free Radical Biology and Aging Research Program

Bulteau,A.L., K.C.Lundberg, M.Ikeda-Saito, G.Isaya, and L.I.Szweda. 2005. Reversible redox-dependent modulation of mitochondrial aconitase and proteolytic activity during in vivo cardiac ischemia/reperfusion. Proc Natl.Acad.Sci.U.S.A 102:5987-5991. [Abstract]

Chaiswing,L., M.P.Cole, W.Ittarat, L.I.Szweda, D.K.St Clair, and T.D.Oberley. 2005. Manganese superoxide dismutase and inducible nitric oxide synthase modify early oxidative events in acute adriamycin-induced mitochondrial toxicity. Mol Cancer Ther. 4:1056-1064. [Abstract]

Churchill,E.N. and L.I.Szweda. 2005. Translocation of deltaPKC to mitochondria during cardiac reperfusion enhances superoxide anion production and induces loss in mitochondrial function. Arch.Biochem Biophys 439:194-199. [Abstract]

Churchill,E.N., C.L.Murriel, C.H.Chen, D.Mochly-Rosen, and L.I.Szweda. 2005. Reperfusion-induced translocation of deltaPKC to cardiac mitochondria prevents pyruvate dehydrogenase reactivation. Circ.Res 97:78-85.[Abstract]

Guo,W.X., Q.N.Pye, K.S.Williamson, C.A.Stewart, K.L.Hensley, Y.Kotake, R.A.Floyd, and R.H.Broyles. 2005. Mitochondrial dysfunction in choline deficiency-induced apoptosis in cultured rat hepatocytes. Free Radic.Biol Med 39:641-650.  [Abstract]

Hensley,K. and R.A.Floyd. 2005. Oxidative modification of proteins in cell signaling. Antioxid.Redox Signal. 7:523-525.

Hensley,K. and K.S.Williamson. 2005. HPLC-Electrochemical Detection of Tocopherol Products as Indicators of Reactive Nitrogen Intermediates. Methods Enzymol. 396:171-182. [Abstract]

Ireland,H., C.J.Konstantoulas, J.A.Cooper, E.Hawe, S.E.Humphries, H.Mather, A.H.Goodall, J.Hogwood, I.Juhan-Vague, J.S.Yudkin, G.di Minno, M.Margaglione, A.Hamsten, G.J.Miller, K.A.Bauer, Y.T.Kim, D.J.Stearns-Kurosawa, and S.Kurosawa. 2005. EPCR Ser219Gly: Elevated sEPCR, prothrombin F1+2, risk for coronary heart disease, and increased sEPCR shedding in vitro. Atherosclerosis 183:283-292. [Abstract]

Kadiiska,M.B., B.C.Gladen, D.D.Baird, D.Germolec, L.B.Graham, C.E.Parker, A.Nyska, J.T.Wachsman, B.N.Ames, S.Basu, N.Brot, G.A.Fitzgerald, R.A.Floyd, M.George, J.W.Heinecke, G.E.Hatch, K.Hensley, J.A.Lawson, L.J.Marnett, J.D.Morrow, D.M.Murray, J.Plastaras, L.J.Roberts, J.Rokach, M.K.Shigenaga, R.S.Sohal, J.Sun, R.R.Tice, D.H.Van Thiel, D.Wellner, P.B.Walter, K.B.Tomer, R.P.Mason, and J.C.Barrett. 2005. Biomarkers of Oxidative Stress Study II: Are oxidation products of lipids, proteins, and DNA markers of CCl(4) poisoning? Free Radic.Biol Med 38:698-710. [Abstract]

Kotake,Y., H.Kishida, D.Nakae, and R.A.Floyd. 2005. Nitric oxide production by primary liver cells isolated from amino Acid diet-fed rats. Methods Enzymol. 396:535-541. [Abstract]

Papin,J.F., R.A.Floyd, and D.P.Dittmer. 2005. Methylene blue photoinactivation abolishes West Nile virus infectivity in vivo. Antiviral Res. 68:84-87. [Abstract]

Perluigi,M., P.H.Fai, K.Hensley, W.M.Pierce, J.B.Klein, V.Calabrese, C.De Marco, and D.A.Butterfield. 2005. Proteomic analysis of 4-hydroxy-2-nonenal-modified proteins in G93A-SOD1 transgenic mice-A model of familial amyotrophic lateral sclerosis. Free Radic.Biol Med 38:960-968. [Abstract]

Poon,H.F., K.Hensley, V.Thongboonkerd, M.L.Merchant, B.C.Lynn, W.M.Pierce, J.B.Klein, V.Calabrese, and D.A.Butterfield. 2005. Redox proteomics analysis of oxidatively modified proteins in G93A-SOD1 transgenic mice-a model of familial amyotrophic lateral sclerosis. Free Radic.Biol Med  39:453-462.  [Abstract]  

Salsman,S.J., K.Hensley, and R.A.Floyd. 2005. Sensitivity of protein tyrosine phosphatase activity to the redox environment, cytochrome C, and microperoxidase. Antioxid.Redox Signal. 7:1078-1088.  [Abstract]

* Scofield, H.R., B.T.Kurien, S.Ganick, M.T.McClain, Q.Pye, J.A.James, R.I.Schneider, R.H.Broyles, M.Bachmann, and K.Hensley. 2005. Modification of lupus-associated 60-kDa Ro protein with the lipid oxidation product 4-hydroxy-2-nonenal increases antigenicity and facilitates epitope spreading. Free Radic.Biol Med 38:719-728. [Abstract]

Tanito,M., M.H.Elliott, Y.Kotake, and R.E.Anderson. 2005. Protein modifications by 4-hydroxynonenal and 4-hydroxyhexenal in light-exposed rat retina. Invest Ophthalmol.Vis.Sci. 46:3859-3868. [Abstract]

Tesiram,Y.A., D.Saunders, and R.A.Towner. 2005. Application of proton NMR spectroscopy in the study of lipid metabolites in a rat hepatocarcinogenesis model. Biochim.Biophys Acta 1737:61-68. [Abstract]    

Tomita,H., Y.Kotake, and R.E.Anderson. 2005. Mechanism of Protection from Light-Induced Retinal Degeneration by the Synthetic Antioxidant Phenyl-N-tert-Butylnitrone. Invest Ophthalmol.Vis.Sci. 46:427-434.  [Abstract]

Towner,R.A., L.M.Foley, and D.M.Painter. 2005. Hepatocarcinogenesis tumor grading correlated with in vivo image-guided (1)H-NMR spectroscopy in a rat model. Toxicol.Appl.Pharmacol. 207(2S):237-244. [Abstract]

Uematsu,F., M.Takahashi, M.Yoshida, M.Igarashi, N.Watanabe, N.Suzuki, M.Abe, I.Rusyn, R.A.Floyd, and D.Nakae. 2005. Distinct patterns of gene expression in hepatocellular carcinomas and adjacent non-cancerous, cirrhotic liver tissues in rats fed a choline-deficient, l-amino acid-defined diet. Cancer Sci. 96:414-424.  [Abstract]

Immunobiology and Cancer Research Program

* Aston,C.E., D.A.Ralph, D.P.Lalo, S.Manjeshwar, B.A.Gramling, D.C.Defreese, A.D.West, D.E.Branam, L.F.Thompson, M.A.Craft, D.S.Mitchell, C.D.Shimasaki, J.J.Mulvihill, and E.R.Jupe. 2005. Oligogenic combinations associated with breast cancer risk in women under 53 years of age. Hum.Genet. 116:208-221. [Abstract]

Baba,Y., K.P.Garrett, and P.W.Kincade. 2005. Constitutively active beta-catenin confers multilineage differentiation potential on lymphoid and myeloid progenitors. Immunity 23:599-609. [Abstract]

Chain,J.L., M.L.Joachims, S.W.Hooker, A.B.Laurent, C.K.Knott-Craig, and L.F.Thompson. 2005. Real-time PCR method for the quantitative analysis of human T-cell receptor gamma and beta gene rearrangements. J Immunol.Methods. 300: 12-23. [Abstract] 

Huang,J., K.P.Garrett, R.Pelayo, J.C.Zuniga-Pflucker, H.T.Petrie, and P.W.Kincade. 2005. Propensity of Adult Lymphoid Progenitors to Progress to DN2/3 Stage Thymocytes with Notch Receptor Ligation. J Immunol 175:4858-4865. [Abstract]

Igarashi,H., K.L.Medina, T.Yokota, M.I.Rossi, N.Sakaguchi, P.C.Comp, and P.W.Kincade. 2005. Early lymphoid progenitors in mouse and man are highly sensitive to glucocorticoids. Int.Immunol. 17:501-511. [Abstract]

Maeda,K., Y.Baba, Y.Nagai, K.Miyazaki, A.Malykhin, K.Nakamura, P.W.Kincade, N.Sakaguchi, and K.M.Coggeshall. 2005. IL-6 blocks a discrete early step in lymphopoiesis. Blood. 106: 879-85. [Abstract] 

Pelayo,R., J.Hirose, J.Huang, K.P.Garrett, A.Delogu, M.Busslinger, and P.W.Kincade. 2005. Derivation of two categories of plasmacytoid dendritic cells in murine bone marrow. Blood. 105: 4407-15. [Abstract]

Pelayo,R., R.Welner, S.S.Perry, J.Huang, Y.Baba, T.Yokota, and P.W.Kincade. 2005. Lymphoid progenitors and primary routes to becoming cells of the immune system. Curr Opin.Immunol. 17:100-107. [Abstract]

Petrie,H.T. and P.W.Kincade. 2005. Many roads, one destination for T cell progenitors. J Exp Med 202:11-13. [Abstract]

Rajaiya,J., M.Hatfield, J.C.Nixon, D.J.Rawlings, and C.F.Webb. 2005. Bruton's Tyrosine Kinase Regulates Immunoglobulin Promoter Activation in Association with the Transcription Factor Bright. Mol Cell Biol 25:2073-2084. [Abstract]

Schmittgen TD, KA Gissel, BA Zakrajsek, BP Lawrence, Q Liu, MR Lerner, SV Do, and DJ Brackett. 2005. Diverse gene expression pattern during 5-fluorouridine-induced apoptosis. Int J Oncol 27:297-306. [Abstract]

Vedham,V., H.Phee, and K.M.Coggeshall. 2005. Vav activation and function as a rac Guanine nucleotide exchange factor in macrophage colony-stimulating factor-induced macrophage chemotaxis. Mol Cell Biol 25:4211-4220. [Abstract]

* Yao,L., T.Yokota, L.Xia, P.W.Kincade, and R.P.McEver. 2005. Bone marrow dysfunction in mice lacking the cytokine receptor gp130 in endothelial cells. Blood 106:4093-101. [Abstract]  

Lipid Studies

Blackett,P.R., K.S.Blevins, E.Quintana, M.Stoddart, W.Wang, P.Alaupovic, and E.T.Lee. 2005. ApoC-III bound to apoB-containing lipoproteins increase with insulin resistance in Cherokee Indian youth. Metabolism 54:180-187.  [Abstract]

Blackett,P.R., K.S.Blevins, M.Stoddart, W.Wang, E.Quintana, P.Alaupovic, and E.T.Lee. 2005. Body mass index and high-density lipoproteins in cherokee Indian children and adolescents. Pediatr.Res 58:472-477. [Abstract]

Kwiterovich,P.O., Jr., S.L.Cockrill, D.G.Virgil, E.S.Garrett, J.Otvos, C.Knight-Gibson, P.Alaupovic, T.Forte, L.Zhang, Z.N.Farwig, and R.D.Macfarlane. 2005. A large high-density lipoprotein enriched in apolipoprotein C-I: a novel biochemical marker in infants of lower birth weight and younger gestational age. JAMA 293:1891-1899. [Abstract]

Wang,W., E.T.Lee, P.Alaupovic, P.Blackett, and K.S.Blevins. 2005. Correlation between lipoprotein(a) and other risk factors for cardiovascular disease and diabetes in Cherokee Indians: the Cherokee Diabetes Study. Ann.Epidemiol. 15:390-397. [Abstract]

Ahonen,L.J., M.J.Kallio, J.R.Daum, M.Bolton, I.A.Manke, M.B.Yaffe, P.T.Stukenberg, and G.J.Gorbsky. 2005. Polo-like Kinase 1 Creates the Tension-Sensing 3F3/2 Phosphoepitope and Modulates the Association of Spindle-Checkpoint Proteins at Kinetochores. Curr Biol 15:1078-1089. [Abstract]

Conchello,J.A. and J.W.Lichtman. 2005. Optical sectioning microscopy. Nat.Methods 2:920-931. [Abstract]

Karpac,J., D.Ostwald, S.Bui, P.Hunnewell, M.Shankar, and U.Hochgeschwender. 2005. Development, Maintenance, and Function of the Adrenal Gland in Early Postnatal Pro-opiomelanocortin Null Mutant Mice. Endocrinology.146: 2555-62.  [Abstract]

Kateneva,A.V., A.A.Konovchenko, V.Guacci, and M.E.Dresser. 2005. Recombination protein Tid1p controls resolution of cohesin-dependent linkages in meiosis in Saccharomyces cerevisiae. J Cell Biol 171:241-253.  [Abstract]  

Lichtman,J.W. and J.A.Conchello. 2005. Fluorescence microscopy. Nat.Methods 2:910-919. {Abstract]

Lu,H. and M.Clarke. 2005. Dynamic properties of Legionella-containing phagosomes in Dictyostelium amoebae. Cell Microbiol. 7:995-1007. [Abstract]

Ren,Q., H.Yang, M.Rosinski, M.N.Conrad, M.E.Dresser, V.Guacci, and Z.Zhang. 2005. Mutation of the cohesin related gene PDS5 causes cell death with predominant apoptotic features in Saccharomyces cerevisiae during early meiosis. Mutat.Res 570:163-173. [Abstract]

Reynolds,N.K., M.A.Schade, and K.G.Miller. 2005. Convergent, RIC-8-dependent Galpha signaling pathways in the Caenorhabditis elegans synaptic signaling network. Genetics 169:651-670. [Abstract]

Schade,M.A., N.K.Reynolds, C.M.Dollins, and K.G.Miller. 2005. Mutations that Rescue the Paralysis of C. elegans ric-8 (Synembryn) Mutants Activate the G{alpha}s Pathway and Define a Third Major Branch of the Synaptic Signaling Network. Genetics 169:631-49. [Abstract] 

Zhang,Z., Q.Ren, H.Yang, M.N.Conrad, V.Guacci, A.Kateneva, and M.E.Dresser. 2005. Budding yeast PDS5 plays an important role in meiosis and is required for sister chromatid cohesion. Mol Microbiol. 56:670-680. [Abstract]

Jackson,S.M. and J.D.Capra. 2005. IgH V-region sequence does not predict the survival fate of human germinal center B cells. J Immunol. 174:2805-2813. [Abstract]

*  Rodgers,W., D.Farris, and S.Mishra. 2005. Merging complexes: properties of membrane raft assembly during lymphocyte signaling. Trends Immunol. 26:97-103.  [Abstract]

Rodgers,W. and K.Smith. 2005. Properties of glycolipid-enriched membrane rafts in antigen presentation. Crit Rev.Immunol. 25:19-30. [Abstract]

Zheng,N.Y., K.Wilson, M.Jared, and P.C.Wilson. 2005. Intricate targeting of immunoglobulin somatic hypermutation maximizes the efficiency of affinity maturation. J Exp Med 201:1467-1478. [Abstract]

Chang,W.P., G.F.Combs, Jr., C.G.Scanes, and J.A.Marsh. 2005. The effects of dietary vitamin E and selenium deficiencies on plasma thyroid and thymic hormone concentrations in the chicken. Dev.Comp Immunol. 29:265-273. [Abstract]

Ghosh,A.K., T.Devasamudram, L.Hong, C.Dezutter, X.Xu, V.Weerasena, G.Koelsch, G.Bilcer, and J.Tang. 2005. Structure-based design of cycloamide-urethane-derived novel inhibitors of human brain memapsin 2 (beta-secretase). Bioorg.Med Chem Lett 15:15-20. [Abstract]

Ghosh,A.K., N.Kumaragurubaran, and J.Tang. 2005. Recent Developments of Structure Based beta-Secretase Inhibitors for Alzheimer's Disease. Curr Top.Med Chem 5:1609-1622. [Abstract]

He,X., F.Li, W.Chang, and J.Tang. 2005. GGA proteins mediate the recycling pathway of memapsin 2 (BACE). J Biol Chem.  280: 11696-703. [Abstract]

Tang,J., X.He, X.Huang, and L.Hong. 2005. Recent developments on the studies of human memapsin 2 (beta-secretase). Curr Alzheimer Res 2:261-264. [Abstract]

Turner,R.T., III, L.Hong, G.Koelsch, A.K.Ghosh, and J.Tang. 2005. Structural locations and functional roles of new subsites S5, S6, and S7 in memapsin 2 (beta-secretase). Biochemistry 44:105-112.  [Abstract]

05/24/07

OMRF Scientific Publications