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Institute description: The Oklahoma Medical Research Foundation is a private, non-profit biomedical research facility specializing in the basic science of human disease. Research at OMRF focuses on the basic molecular mechanisms of cellular, genetic, and metabolic diseases. The Foundation includes 8 distinct programs in the general areas of Immunology, Biochemistry, and Molecular, Cell and Developmental Biology. Many faculty within each program hold adjunct appointments with the corresponding departments at the University of Oklahoma Health Sciences Center (OUHSC).  OUHSC is the degree-granting institution and is partnered with OMRF in graduate education.

  • Research areas: Programs at OMRF include Arthritis & Immunology, Cardiovascular Biology, Clinical Pharmacology, Crystallography, Free Radical Biology & Aging, Immunobiology & Cancer, Molecular, Cell and Developmental Biology,  and Protein Studies. The Foundation generally has 35-40 graduate students within these Program areas.
     
  • Faculty: The Oklahoma Medical Research Foundation houses the state's only Howard Hughes Medical Institute Investigators and only member of the National Academy of Science. In addition to teaching graduate courses at OUHSC, faculty and scientists at OMRF distinguish themselves by serving on a number of national advisory panels at institutes such as the NIH.
     
  • Core Facilities: OMRF maintains core facilities housing particular equipment and expertise.

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    • BIACore, to measure affinity and binding kinetics of macromolecular interactions.
       
    • DNA sequencing, with the daily capacity to run 90 sequences.
       
    • Flow cytometry, with three instruments: the FACScan and FACSCalibur cytometers, capable of three and four color fluorescence analyses, and the MoFlo cytometer capable of high throughput cell sorting.
       
    • Imaging, to assist researchers with imaging needs ranging from basic light and electron microscopy to digital image processing and analysis.
       
    • In Situ Hybridization, including tissue sectioning, slide mounting, and hybridization histochemistry.
       
    • Mouse Genome Manipulation Facility, providing microinjection services of DNA into zygotes for the generation of transgenic mice, and of ES cells into blastocysts for the generation of knockout mice.
       
    • The Molecular Biology Resource Facility, for protein and peptide sequencing and mass spectrometry analysis.
       
    • Signal Transduction Core, to assist research involving intracellular Ca2+ measurements and protein-protein interactions.