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Carl V. Manion, M.D.

Dr. Manion is an MD and is not the lead scientist in most research programs. He asserts the role of research support.

Research Area: Clinical Pharmacology

- Study in hypertension as a part of the ongoing evaluations of the long-term treatment of high blood pressure.

1) Role of Angiotensin receptor blockers (ARB) in improving survival and prevention of strokes and heart attacks better than older treatments.

2) Role of ARB therapy in delaying the onset of adult diabetes.

3) Developing safe medication to lower cholesterol

- Treatment/Medication for childhood/ juvenile Rheumatoid Arthritis.

- Study of therapeutic use of Aspartame (in treating sickle cell anemia and rheumatoid arthritis)

Details of Patents Filed: All technologies are currently under negotiations for exclusive licensing.

Tech. ID	Patent/Patent Application #	Status of the Patent/ Patent Application	Abstract
SA 07300	Patent # 5654334	US Utility Patent - Issued.	Analgesic use of N-L-*Aspartyl-L-Phenylalanine 1-Methyl Ester (also called "Aspartame")
	Patent # 5998473	Continuation-in-part filed in US. Issued	Analgesic use of Aspartame derivatives
	Nationalized PCT # 2225462	Filed in Canada	Analgesic use of Aspartame
	Nationalized PCT	Filed in Japan	Analgesic use of Aspartame
	Patent # 722460	Filed in Australia - Issued	Analgesic use of Aspartame
	Nationalized PCT	Filed in Europe - Published	Analgesic use of Aspartame
	Nationalized PCT	Filed in Hong Kong	Analgesic use of Aspartame
SA 08800	Patent # 6177467	US Utility Patent - Issued	Use of Aspartame and derivatives in Regression of Disease
	Nationalized PCT # 2266098	Filed in Canada	Use of Aspartame and derivatives in Regression of Disease
	Patent# 733075	Filed in Australia - Issued	Use of Aspartame and derivatives in Regression of Disease
	Nationalized PCT	Filed in Japan	Use of Aspartame and derivatives in Regression of Disease
	Nationalized PCT	Filed in Europe	Use of Aspartame and derivatives in Regression of Disease
SA 10200	Patent # 6384076	US Utility Patent - Issued	Inhibition of Erythrocyte sickling by Aspartame
	Nationalized PCT # 2345243	Filed in Canada	Inhibition of Erythrocyte sickling by Aspartame
	Nationalized PCT	Filed in Japan	Inhibition of Erythrocyte sickling by Aspartame
	Nationalized PCT	Filed in Australia	Inhibition of Erythrocyte sickling by Aspartame
	Nationalized PCT	Filed in Monaco	Inhibition of Erythrocyte sickling by Aspartame
	Nationalized PCT	Filed in Germany	Inhibition of Erythrocyte sickling by Aspartame
	Nationalized PCT	Filed in France	Inhibition of Erythrocyte sickling by Aspartame
	Nationalized PCT	Filed in Great Britain	Inhibition of Erythrocyte sickling by Aspartame
	Patent # EP1115414	Filed in Europe - Issued	Inhibition of Erythrocyte sickling by Aspartame
SA 10800	Patent # 6156795	US Utility Patent - Issued	Aspartame & its derivatives for appetite enhancement
SA 10800	Patent # 6326400	Continuation in part filed in US. Issued	Aspartame & its derivatives for appetite enhancement
SA 11000	Nationalized PCT	Filed in the US	Viscosity Modulating Substance & use thereof
	Nationalized PCT# 2385454	Filed in Canada	Viscosity Modulating Substance & use thereof
	Nationalized PCT	Filed in Europe	Viscosity Modulating Substance & use thereof
	Nationalized PCT	Filed in Australia	Viscosity Modulating Substance & use thereof